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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10071138 B1

PDFFull Text
Date of Patent:
Sep. 11, 2018

Filed:

Aug. 19, 2016

Compositions and methods for modulating stem cells and uses thereof

Applicant:

Ottawa Hospital Research Institute, Ottawa, CA;

Inventors:

Michael A. Rudnicki, Ottawa, CA;

Fabien Le Grand, Cachan, FR;

Assignee:

Ottawa Hospital Research Institute, Ottawa, CA;

Attorney:

Weaver Austin Villeneuve & Sampson LLP

Primary Examiner:

Marianne P Allen

Int. Cl.
CPC ...
A61K 35/34 (2015.01); A61K 38/17 (2006.01); C07K 14/475 (2006.01); C07K 14/47 (2006.01); C12N 5/077 (2010.01); A61K 38/18 (2006.01); A61K 48/00 (2006.01); C12N 5/0797 (2010.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); G01N 33/50 (2006.01); A61K 35/545 (2015.01);
U.S. Cl.
CPC ...
A61K 38/18 (2013.01); A61K 35/545 (2013.01); A61K 38/1709 (2013.01); A61K 48/005 (2013.01); C07K 14/4702 (2013.01); C12N 5/0623 (2013.01); C12N 5/0658 (2013.01); C12N 5/0659 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); G01N 33/5073 (2013.01); A61K 35/34 (2013.01); C12N 2310/14 (2013.01); C12N 2501/415 (2013.01); C12N 2800/107 (2013.01);
Abstract

There are provided compositions and methods for modulating stem cell division decisions, in particular, division symmetry. It has been demonstrated that wnt7a acts through frizzled-7 receptor expressed on the surface of adult stem cells, e.g. satellite stem cells, to activate the planar cell polarity (PCP) pathway, thereby promoting symmetrical expansion of stem cells. The compositions and methods of the invention are useful, for example, in modulating stem cell division symmetry in vitro and in vivo, in replenishing and expanding the stem cell pool, and in promoting the formation, maintenance, repair and regeneration of tissue.

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