The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2018
Filed:
May. 26, 2015
National University Corporation Okayama University, Okayama-shi, Okayama, JP;
Momotaro-gene Inc., Okayama-shi, Okayama, JP;
Industry-university Cooperation Foundation Hanyang University, Seongdong-gu, Seoul, KR;
Hiromi Kumon, Okayama, JP;
Yasutomo Nasu, Okayama, JP;
Masami Watanabe, Okayama, JP;
Chae Ok Yun, Seoul, KR;
National University Corporation Okayama University, Okayama, JP;
Momotaro-Gene Inc., Okayama, JP;
Industry-University Cooperation Foundation Hanyang University, Seoul, KR;
Abstract
An object of the present invention is to provide a conditionally replicating adenovirus having a strong anticancer effect. A conditionally replicating adenovirus to replicate specifically in a cancer cell and express REIC protein or REIC C domain protein, wherein the conditionally replicating adenovirus is obtained by inserting full-length REIC DNA or REIC C domain DNA into a conditionally replicating adenovirus comprising an ITR (inverted terminal repeat) sequence of an adenovirus type 5 genome and insertion of an HRE sequence, an hTERT promoter, a decorin-encoding DNA, and a DNA encoding a peptide comprising an RGD sequence.