The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2018
Filed:
Jan. 08, 2016
Applicant:
Idera Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Ekambar R. Kandimalla, Hopkinton, MA (US);
Daqing Wang, Bedford, MA (US);
Dong Yu, Westboro, MA (US);
Ireneusz Nowak, Allston, MA (US);
Sudhir Agrawal, Shrewsbury, MA (US);
Assignee:
Idera Pharmaceuticals, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/117 (2010.01); A61K 39/39 (2006.01); A61K 9/00 (2006.01); A61K 31/711 (2006.01); A61K 45/06 (2006.01); A61K 31/7115 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/117 (2013.01); A61K 9/0019 (2013.01); A61K 31/711 (2013.01); A61K 31/7115 (2013.01); A61K 39/39 (2013.01); A61K 45/06 (2013.01); A61K 2039/55561 (2013.01); C12N 2310/17 (2013.01); C12N 2310/335 (2013.01); C12N 2310/336 (2013.01); C12N 2310/3341 (2013.01); C12N 2320/30 (2013.01); C12N 2320/31 (2013.01); C12N 2710/24043 (2013.01); Y02A 50/414 (2018.01);
Abstract
The invention provides immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.