The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 04, 2018

Filed:

Jul. 28, 2017
Applicant:

Case Western Reserve University, Cleveland, OH (US);

Inventors:

David C. Soler, Cleveland, OH (US);

Andrew E. Sloan, Cleveland, OH (US);

Kevin D. Cooper, Cleveland, OH (US);

Thomas S. McCormick, Cleveland, OH (US);

Andrew B. Young, Cleveland, OH (US);

Assignee:

Case Western Reserve University, Cleveland, OH (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); C07K 16/28 (2006.01); A61K 35/28 (2015.01); C07K 16/30 (2006.01); G01N 33/574 (2006.01); G01N 33/577 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); A61K 35/28 (2013.01); C07K 16/30 (2013.01); G01N 33/574 (2013.01); G01N 33/577 (2013.01); C12N 2501/515 (2013.01);
Abstract

A method of detecting the presence of glioblastomas and/or recurrent glioblastomas in a subject in need thereof includes isolating CD14+ cells from a blood sample of the subject and determining the ratio of isolated CD14+ cells expressing low levels of HLA-DR to isolated CD14+ cells expressing VNN2, wherein the subject has increased risk of glioblastomas or recurrent glioblastoma if the ratio of isolated CD14+ cells expressing low levels of HLA-DR to isolated CD14+ cells expressing VNN2 is greater than about 2.


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