The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2018
Filed:
Aug. 06, 2015
Affimed Gmbh, Heidelberg, DE;
Eugene Zhukovsky, Mannheim, DE;
Melvyn Little, St. Peter-Ording, DE;
Stefan Knackmuss, Plankstadt, DE;
Uwe Reusch, Maikammer, DE;
Kristina Ellwanger, Heidelberg, DE;
Ivica Fucek, Hamburg, DE;
Michael Weichel, Bischofsheim, DE;
Markus Eser, Düsseldorf, DE;
Fionnuala McAleese-Eser, Düsseldorf, DE;
Affirmed GmbH, Heidelberg, DE;
Abstract
The invention relates to a humanized CD3 binding site, which comprises (a) a variable heavy chain domain (VH) as depicted in SEQ ID NO:8 and a variable light chain domain (VL) as depicted in SEQ ID NO:3; or (b) a variable heavy chain domain (VH) as depicted in SEQ ID NO:9 and a variable light chain domain (VL) as depicted in SEQ ID NO:4, or c) a variable heavy chain domain (VH) as depicted in SEQ ID NO:7 and a variable light chain domain (VL) as depicted in SEQ ID NO:2; or (d) a variable heavy chain domain (VH) as depicted in SEQ ID NO:6 and a variable light chain domain (VL) as depicted in SEQ ID NO:1. The CD3 binding sites have an increased stability, while the binding affinity has been retained due to mutations at positions VH111 and VL49.