The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2018
Filed:
Sep. 28, 2017
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Anthony Casarez, San Francisco, CA (US);
Markus Furegati, Allschwil, CH;
Guido Koch, Bettingen, CH;
Xiaodong Lin, Orinda, CA (US);
Flavio Ossola, Liestal, CH;
Folkert Reck, Walnut Creek, CA (US);
Robert Lowell Simmons, San Francisco, CA (US);
Qingming Zhu, Walnut Creek, CA (US);
Assignee:
Novartis AG, Basel, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/18 (2006.01); A61K 31/439 (2006.01); A61K 31/5025 (2006.01); A61K 31/407 (2006.01); A61K 31/427 (2006.01); A61K 31/431 (2006.01); A61K 31/496 (2006.01); A61K 31/546 (2006.01); A61K 31/535 (2006.01); A61P 31/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/18 (2013.01); A61K 31/407 (2013.01); A61K 31/427 (2013.01); A61K 31/431 (2013.01); A61K 31/439 (2013.01); A61K 31/496 (2013.01); A61K 31/5025 (2013.01); A61K 31/535 (2013.01); A61K 31/546 (2013.01); A61P 31/04 (2018.01); C07B 2200/13 (2013.01);
Abstract
This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.