The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2018
Filed:
Jun. 19, 2015
Pentracor Gmbh, Henningsdorf, DE;
Victor Prisyazhnoy, Luckenwalde, DE;
Stephan Mattecka, Berlin, DE;
Ahmed Sheriff, Berlin, DE;
Roderich Süssmuth, Berlin, DE;
Pentracor GmbH, Luckenwalde, DE;
Abstract
The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material of general formula (II), which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also provided is a column that comprises the separation material of general formula (II), as well as a device containing the column. Formula (I), wherein variable X is selected from: —SH, —NHR, —C═CH, —CH═CH, —Nand —CHO; the other variables are as defined in the claims: Formula (II), wherein variable 'A' represents a solid support. 'A' as well as the other variables are defined in detail in the claims.