The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 04, 2018

Filed:

Jul. 13, 2016
Applicant:

Palo Alto Research Center Incorporated, Palo Alto, CA (US);

Inventors:

Peter Kiesel, Palo Alto, CA (US);

Joerg Martini, San Francisco, CA (US);

Eugene M. Chow, Fremont, CA (US);

Scott Uhland, San Jose, CA (US);

Noble M. Johnson, Menlo Park, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61M 5/30 (2006.01); G01N 15/14 (2006.01); G01B 11/14 (2006.01); G01N 15/10 (2006.01); G01N 15/00 (2006.01); A61M 5/20 (2006.01);
U.S. Cl.
CPC ...
A61M 5/3015 (2013.01); G01B 11/14 (2013.01); G01N 15/00 (2013.01); G01N 15/1434 (2013.01); A61M 5/2053 (2013.01); A61M 2205/3306 (2013.01); A61M 2210/04 (2013.01); G01N 2015/0003 (2013.01); G01N 2015/0046 (2013.01); G01N 2015/1075 (2013.01); G01N 2015/1087 (2013.01); G01N 2015/1093 (2013.01);
Abstract

Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.


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