The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 04, 2018

Filed:

Nov. 29, 2016
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Karl Deisseroth, Stanford, CA (US);

Ofer Yizhar, Palo Alto, CA (US);

Lisa Gunaydin, Stanford, CA (US);

Peter Hegemann, Falkensee, DE;

Andre Berndt, Berlin, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07K 1/00 (2006.01); C12N 15/00 (2006.01); A61K 38/16 (2006.01); C07K 14/705 (2006.01); A61N 5/06 (2006.01); C12N 15/85 (2006.01); C07K 14/405 (2006.01); A61K 36/05 (2006.01); A61K 41/00 (2006.01); C12N 13/00 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 38/00 (2006.01); A61N 5/067 (2006.01);
U.S. Cl.
CPC ...
A61K 38/16 (2013.01); A61K 36/05 (2013.01); A61K 41/0023 (2013.01); A61N 5/0601 (2013.01); A61N 5/062 (2013.01); A61N 5/0622 (2013.01); C07K 14/405 (2013.01); C07K 14/705 (2013.01); C12N 7/00 (2013.01); C12N 13/00 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61N 2005/067 (2013.01); A61N 2005/0651 (2013.01); C12N 2740/15041 (2013.01);
Abstract

Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).


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