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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10064889 B1

PDFFull Text
Date of Patent:
Sep. 04, 2018

Filed:

Mar. 23, 2016

Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof

Applicant:

Bioregen Biomedical (Changzhou) Co., Ltd., Jiangsu, CN;

Inventors:

Xiaozheng Shu, Jiangsu, CN;

Weiping Zhong, Jiangsu, CN;

Yunyun Wang, Jiangsu, CN;

Meixia Yu, Jiangsu, CN;

Assignee:

Bioregen Biomedical (Changzhou) Co., Ltd., Changzhou Jiangsu, CN;

Attorney:

MKG LLC

Primary Examiner:

Shaojia A Jiang

Assistant Examiner:

Everett White

Int. Cl.
CPC ...
A61K 31/37 (2006.01); A61K 31/728 (2006.01); A61K 31/573 (2006.01); A61K 45/06 (2006.01); C08B 37/00 (2006.01); C08B 37/08 (2006.01); A61K 31/737 (2006.01); C08J 3/075 (2006.01); C08F 8/34 (2006.01); A61L 31/04 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/738 (2006.01);
U.S. Cl.
CPC ...
A61K 31/737 (2013.01); A61K 9/0024 (2013.01); A61K 9/06 (2013.01); A61K 31/573 (2013.01); A61K 31/728 (2013.01); A61K 31/738 (2013.01); A61K 45/06 (2013.01); A61L 31/04 (2013.01); C08B 37/0069 (2013.01); C08B 37/0072 (2013.01); C08F 8/34 (2013.01); C08J 3/075 (2013.01); C08J 2301/00 (2013.01);
Abstract

The present invention discloses a mercapto-modified biocompatible macromolecule derivative with a low degree of modification. The mercapto-modified biocompatible macromolecule derivative not only maintains the initial structure, physiological function and biocompatibility as much as possible, but also allows the preparation of the biocompatible macromolecule cross-linked material with a low degree of cross-linking through the effectively chemical cross-linking with the introduced mercapto group. The present invention further discloses a disulfide-bond cross-linked biocompatible macromolecule material with a very low degree of cross-linking. The disulfide-bond cross-linked biocompatible macromolecule material not only maintains the initial structure, physiological function and biocompatibility of the biocompatible macromolecule as much as possible, but also effectively prolongs turn over and reduces the solubility of the biocompatible macromolecule in vivo, better meeting the requirements of various clinical applications. The present invention further relates to the application of the disulfide-bond cross-linked biocompatible macromolecule material in the field of medicine and pharmacy.

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