The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2018
Filed:
Jul. 08, 2011
Gregory Stephanopoulos, Winchester, MA (US);
Christian M. Metallo, San Diego, CA (US);
Joanne K. Kelleher, Cambridge, MA (US);
Othon Iliopoulos, Cambridge, MA (US);
Paulo Alexandre Da Costa Gameiro Guerreiro, Cambridge, MA (US);
Gregory Stephanopoulos, Winchester, MA (US);
Christian M. Metallo, San Diego, CA (US);
Joanne K. Kelleher, Cambridge, MA (US);
Othon Iliopoulos, Cambridge, MA (US);
Paulo Alexandre da Costa Gameiro Guerreiro, Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway, including, but not limited to IDH1, isocitrate dehydrogenase 2 (IDH2), aconitase 1 (ACO1), aconitase 2 (ACO2), glutaminase (GLS), glutamate dehydrogenase (GDH) and transaminase, provides effective means of inhibiting tumor growth.