The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2018
Filed:
Aug. 28, 2017
Applicant:
Vtv Therapeutics Llc, High Point, NC (US);
Inventors:
Adnan M. M. Mjalli, Oak Ridge, NC (US);
Maria Carmen Valcarce Lopez, Oak Ridge, NC (US);
Assignee:
vTv Therapeutics LLC, High Point, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/155 (2006.01); A61K 31/425 (2006.01); A61K 31/426 (2006.01); C07D 277/54 (2006.01);
U.S. Cl.
CPC ...
A61K 31/426 (2013.01); A61K 31/155 (2013.01); C07D 277/54 (2013.01);
Abstract
The present invention provides uses of a glucokinase activator in combination with metformin. Uses include treating type 2 diabetes, lowering blood glucose, improving insulin sensitivity, enhancing phosphorylation of glucose, and improving the therapeutic effectiveness of metformin. The invention also provides pharmaceutical compositions that comprise a GK activator and metformin. The invention also provides a salt formed between metformin and a GK activator.