The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
Mar. 13, 2015
Universidad DE Málaga, Málaga, ES;
Servicio Andaluz DE Salud, Seville, ES;
Fundación Pública Andaluza Para LA Investigación DE Málaga En Biomedicina Y Salud (Fimabis), Málaga, ES;
José Lozano Castro, Málaga, ES;
Emilio Alba Conejo, Málaga, ES;
Luis Gustavo Pérez Rivas, Málaga, ES;
José Jerez Aragonés, Málaga, ES;
Nuria Ribelles Entrena, Seville, ES;
Servicio Andaluz de Salud, Sevilla, ES;
Fundacion Publica Andaluza para la Investigacion de Malaga en Biomedicina y Salud (FIMABIS), Malaga, ES;
Universidad de Malaga, Malaga, ES;
Abstract
The invention relates to the field of oncology and cancer treatment. The invention relates to methods for predicting the risk of recurrence of breast tumors using the expression signature of particular miRNAs. Specifically, the invention relates to a method for determining the risk of recurrence of breast cancer which comprises measuring the expression levels of at least one miRNA selected from the group consisting of miR-149-5p (SEQ ID NO: 1), miR-10a-5p, (SEQ ID NO: 2), miR-20b-5p, (SEQ ID NO: 3), miR-30a-3p (SEQ ID NO: 4), and miR-342-5p, (SEQ ID NO: 5) in a sample of the tumor, wherein a change in the expression level of at least one miRNA in the tumor with respect to the expression level in a control sample is indicative of a high risk of recurrence of the tumor. The invention also relates to tools and kits for carrying out the method of the invention.