The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
May. 08, 2013
Medizinische Hochschule Hannover, Hannover, DE (US);
Universitätsmedizin Der Johannes-gutenberg- Universität Mainz, Mainz, DE;
Helge Frieling, Hannover, DE;
André Tadic, Flörsheim am Main, DE;
Stefan Bleich, Uetze (OT Obershagen), DE;
Klaus J. Lieb, Mainz, DE;
Medizineische Hochschule Hannover, Hannover, DE;
Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Mainz, DE;
Abstract
The present invention relates to a method for predicting the non-response or response to a monoaminergic antidepressant of a patient to be treated with a monoaminergic antidepressant comprising the steps: (i) determining the DNA-methylation status of a brain-derived neurotrophic factor (BDNF)-gene promoter in a sample of said patient; (ii) attributing a hypomethylation of said BDNF-gene promoter to the non-response to a monoaminergic antidepressant of said patient; and (iii) attributing normal methylation or hypermethylation of said BDNF-gene promoter to the response to a monoaminergic antidepressant of said patient. Furthermore, a kit and the use of a kit in said method is disclosed.