The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
Jul. 01, 2015
Applicant:
Innate Pharma S.a., Marseilles, FR;
Inventors:
Andrea Velardi, Perugia, IT;
Francois Romagne, La Ciotat, FR;
Assignee:
INNATE PHARMA S.A., Marseilles, FR;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C12N 5/0783 (2010.01); G01N 33/50 (2006.01); A61K 35/12 (2015.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); C07K 16/28 (2013.01); C07K 16/2887 (2013.01); C07K 16/2893 (2013.01); C07K 16/2896 (2013.01); C12N 5/0646 (2013.01); G01N 33/5047 (2013.01); A61K 2035/124 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); G01N 2333/70535 (2013.01); G01N 2500/10 (2013.01);
Abstract
The present invention relates, generally, to methods and compositions for increasing the efficiency of therapeutic antibodies. Their efficiency is enhanced through the increase of the ADCC mechanism. More particularly, the invention relates to the use of a therapeutic antibody in combination with compounds that block an inhibitory receptor or stimulate an activating receptor of an NK cell in order to enhance the efficiency of the treatment with therapeutic antibodies in human subjects.