The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
Apr. 28, 2016
Cytomx Therapeutics, Inc., South San Francisco, CA (US);
Nancy Elizabeth Stagliano, San Francisco, CA (US);
James William West, Bend, OR (US);
Kathryn Kamath, Santa Barbara, CA (US);
Paul Henry Bessette, San Francisco, CA (US);
Fred Gluck, Santa Barbara, CA (US);
Jason Gary Sagert, San Mateo, CA (US);
Patrick Daugherty, Santa Barbara, CA (US);
CytomX Therapeutics, Inc., South San Francisco, CA (US);
Abstract
The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolyzed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolyzing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.