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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10059752 B1

PDFFull Text
Date of Patent:
Aug. 28, 2018

Filed:

Oct. 03, 2014

Esculentin 1a derivatives and uses thereof

Applicants:

Alison Mcdermott, Bellaire, TX (US);

Marialuisa Mangoni, Rome, IT;

Inventors:

Alison McDermott, Bellaire, TX (US);

Marialuisa Mangoni, Rome, IT;

Assignees:

University of Houston System, Houston, TX (US);

Universita' Degli Studi Di Roma La Sapienza, Rome, IT;

Attorney:

Benjamin Aaron Adler

Primary Examiner:

Julie Ha

Assistant Examiner:

Kristina M Hellman

Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01); C07K 14/46 (2006.01); A61L 27/22 (2006.01); A61L 27/34 (2006.01); A61L 27/54 (2006.01); A61L 29/04 (2006.01); A61L 29/08 (2006.01); A61L 29/16 (2006.01); A61L 31/04 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01);
U.S. Cl.
CPC ...
C07K 14/463 (2013.01); A61K 38/1703 (2013.01); A61K 45/06 (2013.01); A61L 27/22 (2013.01); A61L 27/34 (2013.01); A61L 27/54 (2013.01); A61L 29/048 (2013.01); A61L 29/085 (2013.01); A61L 29/16 (2013.01); A61L 31/047 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61K 9/0051 (2013.01); A61L 2300/25 (2013.01); A61L 2300/252 (2013.01); Y02A 50/473 (2018.01); Y02A 50/475 (2018.01); Y02A 50/478 (2018.01); Y02A 50/481 (2018.01); Y02A 50/483 (2018.01);
Abstract

The present invention provides synthetic antibacterial peptides comprising a sequence at least 80% identical to a sequence shown in SEQ ID NO: 2 or the diastereomer thereof with a sequence shown in SEQ ID NO: 3 or pharmaceutical compositions thereof. Also provided are methods for reducing the severity of microbe-induced inflammation and for stimulating wound healing via the synthetic antibacterial peptides. Further provided is a device having a surface with a coating comprising the synthetic antibacterial peptides.

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