The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 28, 2018

Filed:

Feb. 03, 2015
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Harry Chobanian, Kenilworth, NJ (US);

Duane Demong, Kenilworth, NJ (US);

Yan Guo, Kenilworth, NJ (US);

Zhiyong HU, Kenilworth, NJ (US);

Michael Miller, Kenilworth, NJ (US);

Barbara Pio, Kenilworth, NJ (US);

Christopher W. Plummer, Kenilworth, NJ (US);

Dong Xiao, Kenilworth, NJ (US);

Cangming Yang, Kenilworth, NJ (US);

Rui Zhang, Kenilworth, NJ (US);

Inventors:

Harry Chobanian, Aberdeen, NJ (US);

Duane DeMong, Somerset, NJ (US);

Yan Guo, Westfield, NJ (US);

Zhiyong Hu, Livingston, NJ (US);

Michael Miller, Scotch Plains, NJ (US);

Barbara Pio, West Orange, NJ (US);

Christopher W. Plummer, Hoboken, NJ (US);

Dong Xiao, Warren, NJ (US);

Cangming Yang, South River, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/42 (2006.01); A61K 45/06 (2006.01); A61K 31/366 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/44 (2006.01); C07D 231/20 (2006.01); A61K 31/4985 (2006.01); C07D 401/04 (2006.01); C07D 239/52 (2006.01); C07C 217/52 (2006.01); C07D 205/04 (2006.01); C07D 491/056 (2006.01); C07D 265/30 (2006.01); C07D 207/08 (2006.01); C07D 207/10 (2006.01); C07D 207/12 (2006.01); C07D 209/52 (2006.01); C07D 209/54 (2006.01); C07D 211/22 (2006.01); C07D 213/30 (2006.01); C07D 213/64 (2006.01); C07D 213/65 (2006.01); C07D 213/69 (2006.01); C07D 307/86 (2006.01); C07D 307/88 (2006.01); C07C 59/72 (2006.01); C07D 205/12 (2006.01); C07D 213/647 (2006.01);
U.S. Cl.
CPC ...
C07D 211/42 (2013.01); A61K 31/366 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/44 (2013.01); A61K 31/4985 (2013.01); A61K 45/06 (2013.01); C07C 59/72 (2013.01); C07C 217/52 (2013.01); C07D 205/04 (2013.01); C07D 205/12 (2013.01); C07D 207/08 (2013.01); C07D 207/10 (2013.01); C07D 207/12 (2013.01); C07D 209/52 (2013.01); C07D 209/54 (2013.01); C07D 211/22 (2013.01); C07D 213/30 (2013.01); C07D 213/64 (2013.01); C07D 213/647 (2013.01); C07D 213/65 (2013.01); C07D 213/69 (2013.01); C07D 231/20 (2013.01); C07D 239/52 (2013.01); C07D 265/30 (2013.01); C07D 307/86 (2013.01); C07D 307/88 (2013.01); C07D 401/04 (2013.01); C07D 491/056 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2601/10 (2017.05);
Abstract

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.


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