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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10059663 B1

PDFFull Text
Date of Patent:
Aug. 28, 2018

Filed:

Aug. 29, 2014

Aromatic compound and use thereof

Applicant:

Kyoto Pharmaceutical Industries, Ltd., Kyoto, JP;

Inventors:

Hiroaki Shirahase, Kyoto, JP;

Kenji Takahashi, Kyoto, JP;

Yoshimichi Shoji, Kyoto, JP;

Shigemitsu Takeda, Kyoto, JP;

Assignee:

KYOTO PHARMACEUTICAL INDUSTRIES, LTD., Kyoto, JP;

Attorney:

Wenderoth, Lind & Ponack, L.L.P.

Primary Examiner:

Kendra D Carter

Int. Cl.
CPC ...
C07D 205/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 309/12 (2006.01); C07D 319/12 (2006.01); C07D 335/02 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07C 235/84 (2006.01); C07D 295/14 (2006.01); C07D 307/33 (2006.01); C07D 307/20 (2006.01); C07C 237/40 (2006.01); C07D 211/46 (2006.01); C07D 295/15 (2006.01); C07D 295/155 (2006.01);
U.S. Cl.
CPC ...
C07D 205/04 (2013.01); C07C 235/84 (2013.01); C07C 237/40 (2013.01); C07D 211/46 (2013.01); C07D 295/14 (2013.01); C07D 295/15 (2013.01); C07D 295/155 (2013.01); C07D 307/20 (2013.01); C07D 307/33 (2013.01); C07D 309/12 (2013.01); C07D 319/12 (2013.01); C07D 335/02 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01);
Abstract

Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a pharmacologically acceptable salt: [wherein each substituent is as defined in the DESCRIPTION], has low toxicity, shows good pharmacokinetics, has an action to promote bone formation, and is useful for the prophylaxis or treatment of metabolic bone diseases (osteoporosis, fibrous osteitis (hyperparathyroidism), osteomalacia, Paget's disease that influences the systemic bone metabolism parameter etc.) associated with a decrease in the bone formation ability as compared to the bone resorption capacity.

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