The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 28, 2018

Filed:

May. 16, 2013
Applicants:

Translate Bio Ma, Inc., Lexington, MA (US);

The General Hospital Corporation, Boston, MA (US);

Inventors:

Arthur M. Krieg, Cambridge, MA (US);

Romesh Subramanian, Framingham, MA (US);

James McSwiggen, Arlington, MA (US);

Jeannie T. Lee, Boston, MA (US);

Assignees:

Translate Bio MA, Inc., Lexington, MA (US);

The General Hospital Corporation, Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/00 (2013.01); A61K 47/48023 (2013.01); A61K 47/48246 (2013.01); C12N 15/113 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/351 (2013.01);
Abstract

Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of UTRN. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of UTRN. Methods for modulating expression of UTRN using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of UTRN.


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