The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
May. 01, 2015
Applicant:
Bioasis Technologies, Inc., Richmond, CA;
Inventors:
Wilfred Jefferies, Surrey, CA;
Reinhard Gabathuler, Montreal, CA;
Assignee:
Bioasis Technologies, Inc., Guilford, CT (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 49/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); A61K 47/48 (2006.01); C12N 15/113 (2010.01); A61K 9/00 (2006.01); A61K 31/7088 (2006.01); A61K 47/64 (2017.01);
U.S. Cl.
CPC ...
A61K 47/483 (2013.01); A61K 9/0019 (2013.01); A61K 31/7088 (2013.01); A61K 47/644 (2017.08); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3513 (2013.01);
Abstract
Provided are conjugates between p97 (melanotransferrin) and polynucleotides such as small interfering RNA (siRNA) molecules, and related compositions and methods of use thereof, for instance, to facilitate delivery of polynucleotides such as siRNA molecules across the blood-brain barrier (BBB) and/or improve their tissue penetration in CNS and/or peripheral tissues, and thereby treat and/or diagnose various diseases, including those having a central nervous system (CNS) component.