The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
Nov. 30, 2016
Hiroshi Maruta, Brunswick West, Victoria, AU;
Hiroshi Maruta, Victoria, JP;
Hideaki Takahashi, Tokushima, JP;
Yoshihiro Uto, Tokushima, JP;
Binh Cao Quan Ngyuen, Okinawa, JP;
Pham Thi Be Tu, Okinawa, JP;
Shinkichi Tawata, Okinawa, JP;
Other;
Abstract
The present invention relates to a PAK1 blocking compound having a much higher bioavailability and cell permeability than traditional herbal PAK1 blockers or synthetic PAK1 blockers, and the uses thereof for treating cancer or other PAK1 dependent diseases or disorders. This PAK1 blocking compound comprises an ester of an acidic PAK1 blocker, or a pharmaceutically acceptable salt thereof. This PAK1-blocking ester may be prepared by esterifying a PAK1 blocker starting material with an alcohol; and treating the esterified PAK1 blocker with an aromatic azide to generate a 1,2,3-triazolyl derivative.