The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
Aug. 03, 2015
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Anita Chaudhari, Jacksonville, FL (US);
Ananda Chakrabarty, Villa Park, IL (US);
Tapas Das Gupta, River Forest, IL (US);
Arsenio Fialho, Lisbon, PT;
Tohru Yamada, Lombard, IL (US);
Yonghua Zhu, Hillsborough, NJ (US);
Other;
Abstract
The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals. The invention specifically includes mutants with altered Eph binding constants and selectivities.