The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 28, 2018

Filed:

Nov. 03, 2016
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Rossitza Gueorguieva Alargova, Brighton, MA (US);

Craig Antony Dunbar, Needham, MA (US);

Irina Nikolaevna Kadiyala, Newton, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/47 (2006.01); A61K 31/36 (2006.01); A61K 45/06 (2006.01); A61K 31/404 (2006.01); A61K 9/20 (2006.01); A61K 9/16 (2006.01);
U.S. Cl.
CPC ...
A61K 31/47 (2013.01); A61K 9/1652 (2013.01); A61K 9/2054 (2013.01); A61K 31/404 (2013.01); A61K 45/06 (2013.01); A61K 31/36 (2013.01); Y10S 514/851 (2013.01);
Abstract

A pharmaceutical composition comprising Compound 1, (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide, and at least one excipient selected from: a filler, a disintegrant, a surfactant, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering the pharmaceutical composition of Compound 1 are also disclosed.


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