The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 28, 2018

Filed:

Nov. 16, 2015
Applicant:

Brown University, Providence, RI (US);

Inventors:

Anita Shukla, Providence, RI (US);

Shashank Shukla, Burlington, MA (US);

Assignee:

Brown University, Providence, RI (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 38/14 (2006.01); A61K 47/02 (2006.01); A61K 47/36 (2006.01); A61K 9/51 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 38/14 (2013.01); A61K 47/02 (2013.01); A61K 47/36 (2013.01); A61K 9/5115 (2013.01);
Abstract

A tunable antimicrobial-loaded hydrogel formulation has a mechanical strength can be altered by changing the salt composition. The hydrogel formulation is preferably a Gellan film. The ion concentration in the gel material may be altered to obtain the desired gel strength. The hydrogel formulation is layered directly upon a skin area such as burnt skin. The hydrogel formulation includes a dosage of free antibiotic, such as the antibiotic is preferably vancomycin, for rapid release. The hydrogel formulation also includes microparticles and/or nanoparticles such as activated carbon powder that has adsorbed additional antibiotic. The particles are used to aid in attaining a timely or sustained release of the antibiotic drug.


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