The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 21, 2018

Filed:

May. 24, 2016
Applicant:

Emd Millipore Corporation, Burlington, MA (US);

Inventors:

Philip Janmin Lee, Alameda, CA (US);

Paul Ju-Sung Hung, Fremont, CA (US);

Narendra Maheshri, Cambridge, MA (US);

Assignee:

EMD Millipore Corporation, Burlington, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 15/14 (2006.01); B01L 3/00 (2006.01); G01N 33/487 (2006.01); G01N 33/543 (2006.01); G01N 15/00 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1484 (2013.01); B01L 3/502707 (2013.01); B01L 3/502761 (2013.01); G01N 15/1459 (2013.01); G01N 15/1463 (2013.01); G01N 33/487 (2013.01); G01N 33/54366 (2013.01); B01L 2200/0668 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/123 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0655 (2013.01); G01N 15/147 (2013.01); G01N 15/1475 (2013.01); G01N 2015/0065 (2013.01); G01N 2015/1493 (2013.01);
Abstract

The device and method relate to microfluidic particle analysis. The device is designed for trapping particles for solution analysis. Exemplary particles include beads and cells. The device has a microfluidics body, and a microfluidics channel formed in the body for receiving particles at an upstream region thereof. The channel has a deformable wall portion that defines a particle-capture region, and is responsive to a change in fluid pressure applied thereto, to selectively vary the particle-flow dimensions of the capture region. In this way, particles having a given size may be selectively retained in the capture region. In one embodiment, the deformable wall portion is expandable in response to a positive fluid pressure applied within the channel. In another embodiment, the deformable wall portion is expandable in response to a negative pressure applied to a cavity communicating with the wall portion, external to the channel.


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