The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2018
Filed:
Mar. 13, 2014
Fundación Pública Andaluza Progreso Y Salud, Seville, ES;
Instituto DE Salud Carlos Iii, Madrid, ES;
Francisco Martín Molina, Seville, ES;
Karim Benabdellah, Seville, ES;
Pilar Muñoz Fernández, Seville, ES;
Marién Cobo Pulido, Seville, ES;
Alejandra Gutierrez Guerrero, Seville, ES;
FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD, Seville, ES;
INSTITUTO DE SALUD CARLOS III, Madrid, ES;
Abstract
The present invention solves the problem of providing more efficient barrier insulators to avoid vector silencing and to increase expression in the setting of gene transfer vectors, more particularly in the setting of gene transfer retroviral vectors. In this sense, the authors of the present invention have developed an improved insulator element, namely element IS2, which comprises the following combination of nucleic acid molecules, namely nucleic acid molecule HS4-650 bp as shown in SEQ ID No 2 and a synthetic S/MAR nucleic acid molecule containing 5 M/SARs recognition signatures (MRS) as shown in SEQ ID no 1.