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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10053492 B1

PDFFull Text
Date of Patent:
Aug. 21, 2018

Filed:

Mar. 17, 2017

Red genetically encoded calcium indicators and methods of use

Applicant:

Howard Hughes Medical Institute, Chevy Chase, MD (US);

Inventors:

Douglas S. Kim, Reston, VA (US);

Loren L. Looger, Sterling, VA (US);

Eric R. Schreiter, Leesburg, VA (US);

Karel Svoboda, Leesburg, VA (US);

Assignee:

HOWARD HUGHES MEDICAL INSTITUTE, Chevy Chase, MD (US);

Attorneys:

Stites & Harbison, PLLC

Mandy Wilson Decker

Primary Examiner:

Chang-Yu Wang

Int. Cl.
CPC ...
C07H 21/04 (2006.01); C07H 19/00 (2006.01); C07H 21/00 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/11 (2006.01); C12N 15/13 (2006.01); A61K 48/00 (2006.01); C12Q 1/68 (2018.01); C07K 14/00 (2006.01); A01K 67/027 (2006.01); G01N 33/58 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/00 (2013.01); A01K 67/0275 (2013.01); A61K 49/0045 (2013.01); G01N 33/582 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2227/40 (2013.01); A01K 2227/703 (2013.01); A01K 2227/706 (2013.01); A01K 2267/0393 (2013.01); C12N 2750/14143 (2013.01);
Abstract

Protein indicators useful for calcium imaging, in particular, red genetically-encoded calcium indicators (GECIs) disclosed herein rival best-of-class green GECIs in terms of sensitivity for detecting neural activity, and can be monitored in vivo. The presently-disclosed subject matter further includes a method of monitoring cell activity comprising stimulating a cell comprising a red GECI polypeptide; and detecting fluorescence emitted by the cell.

Find Patent Forward Citations

Kim, Douglas. (2018). Red genetically encoded calcium indicators and methods of use (U.S. Patent No. 10053492). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10053492

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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