The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2018
Filed:
Oct. 11, 2017
King Saud University, Riyadh, SA;
Sartaj Tabassum, Riyadh, SA;
Hamad A. Al-Lohedan, Riyadh, SA;
Hazem Ghabour, Riyadh, SA;
Mohd Sajid Ali, Riyadh, SA;
Rais Ahmad Khan, Riyadh, SA;
Fohad Mabood Husain, Riyadh, SA;
KING SAUD UNIVERSITY, Riyadh, SA;
Abstract
The anti-quorum and DNA cleaving agent is directed to a ruthenium complex formulated from dichloro-(η-p-cymene) ruthenium(II) dimer and 2-chloroquinoxaline, the complex having the formula: The reaction cleaves the dimer, leaving a half-sandwich ruthenium complex with an ηcoordination bond to the arene ligand and an Ru—N bond attaching the chloroquinoxaline to the ruthenium complex. The agent has an anti-quorum sensing effect on bacteria, inhibiting the formation of biofilm and inhibiting bacterial virulence. The agent also binds to DNA and may cleave the DNA, e.g., at the N7 base pair of guanine, due to a hydrolytic mechanism, suggesting potential use as an anticancer or antitumor agent.