IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10053469 B1

PDFFull Text
Date of Patent:
Aug. 21, 2018

Filed:

Sep. 30, 2016

Pyridone and aza-pyridone compounds and methods of use

Applicants:

Gilead Connecticut, Inc., Foster City, CA (US);

Genentech Inc., South San Franciso, CA (US);

Inventors:

Antonio J. M. Barbosa, Middlebury, CT (US);

Peter A. Blomgren, North Branford, CT (US);

Kevin S. Currie, North Branford, CT (US);

Ravi Krishnamoorthy, Guilderland, NY (US);

Jeffrey E. Kropf, Branford, CT (US);

Seung H. Lee, Branford, CT (US);

Scott A. Mitchell, East Haven, CT (US);

Daniel Ortwine, San Ramon, CA (US);

Aaron C. Schmitt, Hamden, CT (US);

Xiaojing Wang, Foster City, CA (US);

Jianjun Xu, Madison, CT (US);

Wendy Young, San Mateo, CA (US);

Honglu Zhang, Guilderland, NY (US);

Zhongdong Zhao, Guilford, CT (US);

Pavel E. Zhichkin, Delmar, NY (US);

Assignees:

GILEAD CONNECTICUT, INC., Foster City, CA (US);

GENENTECH INC., South San Franciso, CA (US);

Attorney:

Millen, White, Zelano & Branigan, PC

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
C07D 519/00 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01); A61K 31/497 (2006.01); A61K 31/4985 (2006.01); A61K 31/501 (2006.01); A61K 31/5025 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/5383 (2006.01); A61K 31/5386 (2006.01); A61K 31/551 (2006.01); A61K 45/06 (2006.01); C07D 471/14 (2006.01); C07C 69/65 (2006.01); C07D 209/52 (2006.01); C07F 5/04 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); A61K 31/497 (2013.01); A61K 31/4985 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5025 (2013.01); A61K 31/5377 (2013.01); A61K 31/5383 (2013.01); A61K 31/5386 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); C07C 69/65 (2013.01); C07D 209/52 (2013.01); C07D 471/14 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01); C07F 5/04 (2013.01);
Abstract

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

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