The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2018
Filed:
Nov. 25, 2014
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Mary Chaves, Arlington, MA (US);
Matthew Bio, Belmont, MA (US);
Matthew Peterson, Hopkinton, MA (US);
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 409/14 (2006.01); A61K 31/506 (2006.01); C07C 309/04 (2006.01); C07C 309/30 (2006.01);
U.S. Cl.
CPC ...
C07D 409/14 (2013.01); C07C 309/04 (2013.01); C07C 309/30 (2013.01); C07B 2200/13 (2013.01);
Abstract
The present invention relates to crystalline forms and co-crystal forms of pharmaceutically acceptable salts of the compound, N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine (AMG 900, and pharmaceutical compositions comprising said crystalline and co-crystal forms thereof. The invention further provides uses of the crystalline forms and compositions, to treat cancer, including various types of solid tumors and hematologic cancer including myeloma and leukemia.