The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2018
Filed:
Sep. 15, 2015
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Yissum Research Development Company of the Hebrew University Ltd, Jerusalem, IL;
Richard Kolesnick, New York, NY (US);
Yechezkel Barenholz, Jerusalem, IL;
Erez Koren, Ramat Hasharon, IL;
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
Yissum Research Development Company of the Hebrew University LTD, Jerusalem, IL;
Abstract
Based on the observation that the application of small amounts of exogenous acid sphingomyelinase to generate endogenous ceramide, or provision of exogenous long-chain natural C16-ceramide resulted in rapid translocation of vacuolar daunorubicin into the nucleus in multi-drug resistant (MDR) cells, the present invention relates to a nano-liposomal preparation that includes C16-ceramide. Exposure of MDR cells to the C16:0 ceramide-based nanoliposomes provide a mechanism to reverse MDR in chemoresistant cells and tumors, by inducing rapid translocation of chemotherapeutic agent from cytoplasmic vesicles to the nucleus.