The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2018
Filed:
Jan. 09, 2014
Zonhon Biopharma Institute Inc., Changzhou, Jiangsu, CN;
Gensun Institute of Biomedicine Co.,ltd., Wujin Changzhou, Jiangsu, CN;
Bruce Yong Ma, Jiangsu, CN;
Jun Wang, Jiangsu, CN;
Jing Qiu, Jiangsu, CN;
Dinglong Wu, Jiangsu, CN;
Chunlin Xu, Jiangsu, CN;
Chen Chen, Jiangsu, CN;
Yaofang Wang, Jiangsu, CN;
ZONHON BIOPHARMA INSTITUTE INC., Changzhou, CN;
GENSUN INSTITUTE OF BIOMEDICINE CO., LTD., Changzhou, CN;
Abstract
The present invention relates to polyethylene glycol (PEG) modified protein drugs, and a PEGylated tissue kallikrein, a preparation method and use thereof are disclosed. The tissue kallikrein has a sequence as shown in SEQ ID No. 1 or SEQ ID No. 2, and the tissue kallikrein may be natural or recombinant. The PEG has a molecular weight of 20 to 40 kDa, and is conjugated to the N-terminal primary amino of the tissue kallikrein. In addition to the advantages of significantly extended half-life, significantly reduced immunogenicity and stable and uniform structure, the biological activity of the PEGylated KLK1 provided in the present invention is improved to a higher extent, which is more significant in the treatment of cerebral apoplexy and diabetic nephropathy in particular.