The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2018
Filed:
Mar. 11, 2016
Applicant:
Q-state Biosciences, Inc., Cambridge, MA (US);
Inventors:
Joel Kralj, Somerville, MA (US);
Graham Dempsey, Cambridge, MA (US);
Christopher Werley, Cambridge, MA (US);
Adam Cohen, Cambridge, MA (US);
Assignee:
Q-STATE BIOSCIENCES, INC., Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); C12N 5/077 (2010.01); G01N 21/64 (2006.01); G01N 33/50 (2006.01); G01N 33/84 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6872 (2013.01); C12N 5/0657 (2013.01); G01N 21/6428 (2013.01); G01N 33/5014 (2013.01); G01N 33/5041 (2013.01); G01N 33/84 (2013.01); G01N 21/6458 (2013.01); G01N 2800/326 (2013.01);
Abstract
Screening compounds by exposing a plurality of cardiomyocytes to a compound, wherein the cardiomyocytes express an optogenetic reporter of membrane potential and an optogenetic reporter of calcium level; receiving light from the optogenetic reporter of membrane potential; creating an AP waveform using the received light; and analyzing the AP waveform to determine the presence or absence of a risk for arrhythmia associated with the compound.