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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10048272 B1

PDFFull Text
Date of Patent:
Aug. 14, 2018

Filed:

Feb. 02, 2016

High-affinity small molecule formylpeptide receptor ligands from screening of combinatorial mixture-based libraries

Applicants:

Stc.unm, Albuquerque, NM (US);

Torrey Pines Institute for Molecular Studies, Port St Lucie, FL (US);

Inventors:

Bruce S. Edwards, Albuquerque, NM (US);

Larry A. Sklar, Albuquerque, NM (US);

Clemencia Pinilla, Cardiff, CA (US);

Richard A. Houghten, Vero Beach, FL (US);

Jon R. Appel, Cardiff, CA (US);

Marc A. Giulianotti, Vero Beach, FL (US);

Jose Medina-Franco, Port St Lucie, FL (US);

Assignees:

STC.UNM, Albuquerque, NM (US);

Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL (US);

Attorneys:

Henry D. Coleman

R. Neil Sudol

Primary Examiner:

Raymond J Henley, III

Int. Cl.
CPC ...
A61K 31/497 (2006.01); A61K 31/517 (2006.01); A61K 31/17 (2006.01); G01N 33/68 (2006.01); C07D 403/14 (2006.01); A61K 31/496 (2006.01); A61K 45/06 (2006.01); C07C 275/28 (2006.01); C40B 30/02 (2006.01); G01N 33/74 (2006.01); A61K 38/00 (2006.01); C07D 241/08 (2006.01); C07K 1/04 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6845 (2013.01); A61K 31/17 (2013.01); A61K 31/496 (2013.01); A61K 45/06 (2013.01); C07C 275/28 (2013.01); C07D 403/14 (2013.01); C40B 30/02 (2013.01); G01N 33/74 (2013.01); A61K 38/00 (2013.01); B01J 2219/00585 (2013.01); C07D 241/08 (2013.01); C07K 1/047 (2013.01); G01N 2333/726 (2013.01);
Abstract

The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.

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