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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10047074 B1

PDFFull Text
Date of Patent:
Aug. 14, 2018

Filed:

Aug. 13, 2015

Pharmaceutical compound

Applicant:

Iomet Pharma Ltd., Edinburgh, Midlothian, GB;

Inventors:

Phillip M. Cowley, Edinburgh, GB;

Alan Wise, Edinburgh, GB;

Margaret Huggett, Dundee, GB;

Assignees:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Iomet Pharma LTD., Midlothian, GB;

Attorneys:

Yong Zhao

Catherine D. Fitch

Primary Examiner:

Sahar Javanmard

Int. Cl.
CPC ...
C07D 413/12 (2006.01); C07D 233/88 (2006.01); C07D 257/06 (2006.01); C07D 261/14 (2006.01); C07D 413/04 (2006.01); A61K 31/415 (2006.01); A61K 31/455 (2006.01); A61K 31/4164 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); C07D 261/16 (2006.01); A61K 31/4155 (2006.01); A61K 31/41 (2006.01);
U.S. Cl.
CPC ...
C07D 413/12 (2013.01); A61K 31/41 (2013.01); A61K 31/415 (2013.01); A61K 31/4155 (2013.01); A61K 31/4164 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); C07D 233/88 (2013.01); C07D 257/06 (2013.01); C07D 261/14 (2013.01); C07D 261/16 (2013.01); C07D 413/04 (2013.01);
Abstract

Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the following formula (I): wherein Xis selected from C and N; Xand Xmay be the same or different and each is independently selected from C, N, O and S; Y is selected from N and O; Z is selected from C, N and O; each bond represented by a dotted line may independently be a double bond or a single bond, provided that valencies at each ring atom are maintained and provided that the ring Q contains at least one double bond and provided that the atom N has a double bond; Rand Rmay be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of Rgroups present is such that the valency of Xis maintained, and the number of Rgroups present is such that the valency of Xis maintained; each Rand Rmay be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of Rand Rgroups present is such that the valency of Z is maintained; Ris selected from H and a substituted or unsubstituted organic group; Rmay be present or absent and is selected from H and a substituted or unsubstituted organic group; and Cy is a cyclic organic group.

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