IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10047051 B1

PDFFull Text
Date of Patent:
Aug. 14, 2018

Filed:

May. 25, 2016

Substituted pyridines and method of use

Applicants:

Abbvie S.á{acute Over (.)}r.l., Luxembourg, LU;

Galapagos NV, Mechelen, BE;

Inventors:

Robert J. Altenbach, Chicago, IL (US);

Marlon D. Cowart, Round Lake Beach, IL (US);

Tom Roger Lisette De Munck, Mechelen, BE;

Sébastien Jean Jacques Cédric Dropsit Montovert, Aulnay sous bois, FR;

Gregory A. Gfesser, Lindenhurst, IL (US);

Hans Kelgtermans, Mechelen, BE;

Sébastien Laurent Xavier Martina, Mechelen, BE;

Steven Emiel Van der Plas, Mechelen, BE;

Xueqing Wang, Northbrook, IL (US);

Assignees:

AbbVie S.á.r.l., Luzembourg, LU;

Galapagos NV, Mechelen, BE;

Attorney:

Quarles & Brady LLP

Primary Examiner:

Samira Jean-Louis

Int. Cl.
CPC ...
C07D 213/81 (2006.01); C07D 213/76 (2006.01); C07D 401/12 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4439 (2006.01); A61K 31/4545 (2006.01); A61K 31/506 (2006.01); A61K 31/513 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 213/81 (2013.01); A61K 31/44 (2013.01); A61K 31/443 (2013.01); A61K 31/4427 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 491/107 (2013.01);
Abstract

The invention discloses compounds of Formula I wherein X, R, R, and Rare as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

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