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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10047034 B1

PDFFull Text
Date of Patent:
Aug. 14, 2018

Filed:

May. 07, 2013

Polyhydroxylated pentacyclic triterpene acids as hmg-coa reductase inhibitors

Applicants:

Joachim Hans, Holzminden, DE;

Torsten Grothe;

Inventors:

Joachim Hans, Holzminden, DE;

Kathrin Reinhardt, Münster, DE;

Torsten Grothe, Affoltern am Albis, CH;

Ingo Wöhrle, Dortmund, DE;

Jana Moldenhauer, Dortmund, DE;

Bärbel Köpcke, Dortmund, DE;

Thomas Küper, Reken, DE;

Jens Bitzer, Dortmund, DE;

Assignee:

Prairie Berry Europe GmbH, Hannover, DE;

Attorneys:

Edward E. Sowers

Brannon Sowers & Cracraft PC

Primary Examiner:

Jean P Cornet

Int. Cl.
CPC ...
A01N 37/00 (2006.01); A61K 31/19 (2006.01); C07C 62/32 (2006.01); A61K 45/06 (2006.01); A61K 31/01 (2006.01); A61K 31/015 (2006.01); A61K 31/191 (2006.01); A61K 31/192 (2006.01); A61K 31/352 (2006.01); A61K 31/7048 (2006.01); A61K 36/73 (2006.01); A61K 9/46 (2006.01); A61K 47/26 (2006.01); A61K 47/46 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A23C 9/13 (2006.01); A23C 9/133 (2006.01); A23C 9/156 (2006.01); A23C 11/02 (2006.01); A23C 15/16 (2006.01); A23L 2/39 (2006.01); A23L 2/40 (2006.01); A23L 2/52 (2006.01); A23G 9/32 (2006.01); A21D 2/16 (2006.01); A21D 2/36 (2006.01); A21D 8/04 (2006.01); A23D 7/005 (2006.01); A23L 7/126 (2016.01); A23L 27/10 (2016.01); A23L 27/60 (2016.01); A23L 33/105 (2016.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07C 62/32 (2013.01); A21D 2/165 (2013.01); A21D 2/36 (2013.01); A21D 8/047 (2013.01); A23C 9/133 (2013.01); A23C 9/1315 (2013.01); A23C 9/1322 (2013.01); A23C 9/156 (2013.01); A23C 9/1565 (2013.01); A23C 11/02 (2013.01); A23C 15/16 (2013.01); A23D 7/0056 (2013.01); A23G 9/32 (2013.01); A23L 2/39 (2013.01); A23L 2/40 (2013.01); A23L 2/52 (2013.01); A23L 7/126 (2016.08); A23L 27/10 (2016.08); A23L 27/60 (2016.08); A23L 33/105 (2016.08); A61K 9/0007 (2013.01); A61K 9/2018 (2013.01); A61K 9/2027 (2013.01); A61K 9/485 (2013.01); A61K 9/4866 (2013.01); A61K 9/4891 (2013.01); A61K 31/01 (2013.01); A61K 31/015 (2013.01); A61K 31/191 (2013.01); A61K 31/192 (2013.01); A61K 31/352 (2013.01); A61K 31/7048 (2013.01); A61K 36/73 (2013.01); A61K 45/06 (2013.01); A61K 47/26 (2013.01); A61K 47/46 (2013.01); A23C 2260/152 (2013.01); A61K 9/0095 (2013.01);
Abstract

The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-CoA reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.

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