The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2018
Filed:
Feb. 26, 2014
Hanmi Pharm. Co., Ltd., Hwaseong-si, Gyeonggi-do, KR;
Myung Hyun Jang, Seoul, KR;
Dae Jin Kim, Hwaseong-si, KR;
Sang Youn Hwang, Hwaseong-si, KR;
Hyun Uk Kim, Busan, KR;
Sung Youb Jung, Suwon-si, KR;
Se Chang Kwon, Seoul, KR;
HANMI PHARM. CO., LTD, Hwaseong-si, KR;
Abstract
Provided are an insulin conjugate having improved insulin receptor binding affinity and increased activity, in which a non-peptidyl polymer and an immunoglobulin Fc region are site-specifically linked to an amino acid residue of the insulin beta chain excluding the N-terminus thereof via a covalent bond, a long-acting formulation including the same, and a preparation method thereof. The insulin conjugate of the present invention is used to provide an insulin formulation which exhibits a remarkably increased in vivo activity of the peptide.