The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2018
Filed:
Nov. 23, 2016
Applicant:
Jakpharm, Llc, Woodbridge, CT (US);
Inventor:
Haiching Ma, Malvern, PA (US);
Assignee:
JAKPharm, LLC, Woodbridge, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/42 (2006.01); C07D 403/10 (2006.01); A61K 31/498 (2006.01);
U.S. Cl.
CPC ...
A61K 31/498 (2013.01); C07D 241/42 (2013.01); C07D 403/10 (2013.01);
Abstract
The present disclosure relates to methods of modulating (for example, inhibiting) activity of JAK3, comprising contacting the JAK3 with a compound of Formula I or pharmaceutically acceptable salt thereof, wherein constituent members are provided hereinwith. The present disclosure further provides novel compounds and compositions as well as their methods of preparation and use. The disclosed JAK3 inhibitors may be used in the treatment of JAK3-associated diseases including, for example, inflammatory and autoimmune disorders.