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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10040846 B1

PDFFull Text
Date of Patent:
Aug. 07, 2018

Filed:

Feb. 22, 2013

Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer

Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

Matthew J. Frigault, Philadelphia, PA (US);

Yangbing Zhao, Cherry Hill, NJ (US);

John Scholler, Narberth, PA (US);

Carl H. June, Merion Station, PA (US);

Assignee:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Attorneys:

Saul Ewing Arnstein & Lehr LLP

Kathryn Doyle

Primary Examiner:

Janice Li

Int. Cl.
CPC ...
A01N 63/00 (2006.01); C12N 15/00 (2006.01); C07K 16/18 (2006.01); C12N 5/0783 (2010.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C12N 5/0636 (2013.01); C07K 2319/33 (2013.01); C12N 2510/00 (2013.01);
Abstract

The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.

Find Patent Forward Citations

Frigault, Matthew. (2018). Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer (U.S. Patent No. 10040846). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10040846

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