The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2018
Filed:
Oct. 22, 2015
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
James A. Wells, Burlingame, CA (US);
Juan Diaz, Colma, CA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C40B 30/04 (2006.01); C07K 16/00 (2006.01); G01N 33/68 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/005 (2013.01); G01N 33/6845 (2013.01); G01N 33/6854 (2013.01); C07K 16/28 (2013.01); C07K 16/2878 (2013.01); C40B 30/04 (2013.01);
Abstract
The invention described herein features methods of isolating monoclonal antibodies or polypeptides that bind to a cell surface expressed antigen. The method of catch and release utilizes engineered protease site for cleavage antigen-antibody or antigen-polypeptide complexes. In some embodiments the protease cleavage site to cleave the complexes is an exogenous protease to mammalian cell. In various embodiments the protease cleavage site to cleave the complexes is an endogenous protease to mammalian cell.