The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2018
Filed:
Oct. 01, 2015
Daiichi Sankyo Company, Limited, Chuo-ku, Tokyo, JP;
National Cancer Center, Chuo-ku, Tokyo, JP;
Shoichi Saito, Shinagawa-ku, JP;
Masao Itoh, Shinagawa-ku, JP;
Tetsunori Fujisawa, Edogawa-ku, JP;
Hironao Saito, Shinagawa-ku, JP;
Yohei Kiyotsuka, Shinagawa-ku, JP;
Hideaki Watanabe, Shinagawa-ku, JP;
Hironori Matsunaga, Shinagawa-ku, JP;
Yoshiko Kagoshima, Shinagawa-ku, JP;
Tetsuya Suzuki, Shinagawa-ku, JP;
Yoko Ogawara, Chuo-ku, JP;
Kazuo Kitabayashi, Chuo-ku, JP;
Daiichi Sankyo Company, Limited, Chuo-ku, JP;
National Cancer Center, Chuo-ko, JP;
Abstract
It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R, R, R, Y, and Z are as defined in claim