The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 07, 2018

Filed:

Nov. 30, 2016
Applicant:

Emory University, Atlanta, GA (US);

Inventors:

Jianxiong Jiang, Decatur, GA (US);

Thota Ganesh, Alpharetta, GA (US);

Yuhong Du, Atlanta, GA (US);

Pahk Thepchatri, Atlanta, GA (US);

Yi Quan, Decatur, GA (US);

Ray J. Dingledine, Atlanta, GA (US);

Assignee:

Emory University, Atlanta, GA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/12 (2006.01); A61K 31/404 (2006.01); A61K 31/4184 (2006.01); C07D 209/08 (2006.01); C07D 235/08 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); A61K 31/404 (2013.01); A61K 31/4184 (2013.01); C07D 209/08 (2013.01); C07D 235/08 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01);
Abstract

The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.


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