The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2018
Filed:
Aug. 14, 2015
Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);
David Carroll, San Francisco, CA (US);
Arvinder Sran, Fremont, CA (US);
Rajinder Singh, Belmont, CA (US);
Jianing Huang, Foster City, CA (US);
Lyuben Tsvetkov, Foster City, CA (US);
Sarkiz Issakani, Redwood City, CA (US);
Donald Payan, Hillsborough, CA (US);
Simon Shaw, Oakland, CA (US);
RIGEL PHARMACEUTICALS, INC., South San Francisco, CA (US);
Abstract
Disclosed are sulfonamidoquinoline compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R, R, Rand Rare as described herein. In certain embodiments, a compound disclosed herein inhibits ubiquitination, and can be used to treat disease by blocking the degradation of tumor suppressors.