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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10039844 B1

PDFFull Text
Expired
Date of Patent:
Aug. 07, 2018

Filed:

Dec. 02, 2015

Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase m2

Applicant:

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Inventors:

Timothy Witney, Denton, GB;

Michelle L. James, Menlo Park, CA (US);

Sanjiv S. Gambhir, Portola Valley, CA (US);

Assignee:

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Attorney:

Thomas | Horstemeyer, LLP

Primary Examiner:

Michael G Hartley

Assistant Examiner:

Sean R Donohue

Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61K 51/04 (2006.01); C07D 295/26 (2006.01); G01N 33/574 (2006.01); G01N 33/60 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0459 (2013.01); C07D 295/26 (2013.01); G01N 33/57496 (2013.01); G01N 33/60 (2013.01); G01N 2333/91215 (2013.01);
Abstract

A novel pyruvate kinase M2 (PKM2)-specific activator, [C]DASA-23 and derivatives thereof, and methods for their rapid synthesis are provided. The probes are particularly useful in methods for the non-invasive positron emission tomography (PET) detection and imaging of PKM2 expression in subcutaneous and orthotopic tumors. [C]DASA-23 cell uptake correlates with PKM2 protein expression in cultured tumor cells and orthotopic tumors are delineated from the surrounding normal brain tissue in vivo.

Find Patent Forward Citations

Witney, Timothy. (2018). Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase m2 (U.S. Patent No. 10039844). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10039844

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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