The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2018
Filed:
Apr. 14, 2017
Applicant:
Strongbridge Biopharma Plc, Dublin, IE;
Inventor:
Michel Afargan, Ra'anana, IL;
Assignee:
Strongbridge Ireland Limited, Trevose, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2006.01); A61K 47/36 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61K 9/14 (2006.01);
U.S. Cl.
CPC ...
A61K 38/08 (2013.01); A61K 9/0019 (2013.01); A61K 9/5031 (2013.01); A61K 9/5089 (2013.01); A61K 47/36 (2013.01);
Abstract
The present invention provides compositions comprising water soluble peptides with poor solubility in isotonic solutions which exhibit enhanced bioavailability with reduced adverse effects including injection site reactions. Methods are also disclosed for using such compositions for the treatment of diseases including, but not limited to, cancer, type 2 diabetes, acromegaly, metabolic disorders, endocrine disorders, exocrine tumors, and hormone-related tumors. Methods to reduce adverse injection site reactions and improve bioavailability are also disclosed.