The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2018
Filed:
Nov. 20, 2017
Glaxo Group Limited, Brentford, GB;
Stephen John Atkinson, Stevenage, GB;
Michael David Barker, Stevenage, GB;
Matthew Campbell, Stevenage, GB;
Hawa Diallo, Stevenage, GB;
Clement Douault, Stevenage, GB;
Neil Stuart Garton, Stevenage, GB;
John Liddle, Stevenage, GB;
Robert John Sheppard, Stevenage, GB;
Ann Louise Walker, Stevenage, GB;
Christopher Wellaway, Stevenage, GB;
David Matthew Wilson, Stevenage, GB;
Glaxo Group Limited, Brentford, GB;
Abstract
Compounds of formula (I) wherein; Ris hydrogen or Calkyl; Ris hydrogen, Calkyl, perhalomethylCalkyl-O—, or Calkoxy; Ris hydrogen, Calkyl, or CalkoxyCalkyl; Ris hydrogen, Calkyl, perhalomethylCalkyl; or unsubstituted CcycloalkylCalkyl; A is C—Ror N; B is C—Ror N; D is C—Ror N; with the proviso that at least one of A, B, and D, is N; Ris hydrogen or Calkyl; Ris hydrogen or Calkyl; Ris hydrogen, Calkyl, Calkoxy, or hydroxy; Ris hydrogen or Calkyl, with the proviso that one of Rand Ris hydrogen; Ris hydrogen or hydroxy; Ris hydrogen or Calkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.