The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2018
Filed:
Dec. 15, 2016
Tianjin Chase Sun Pharmaceutical Co., Ltd., Tianjin, CN;
The First Affiliated Hospital, Third Military Medical University, Pla, Chongqing, CN;
Jiang Zheng, Chongqing, CN;
Xin Liu, Chongqing, CN;
Xinchuan Zheng, Chongqing, CN;
Hong Zhou, Chongqing, CN;
Hongwei Cao, Chongqing, CN;
Ning Wang, Chongqing, CN;
Yongling Lu, Chongqing, CN;
Tianjin Chase Sun Pharmaceutical Co., Ltd, Tianjin, CN;
The First Affiliated Hospital, Third Military Medical University, PLA, Shapingba District, Chongqing, CN;
Abstract
The use of Kukoamine A and Kukoamine B in the preparation of drugs for the prevention and treatment of sepsis and autoimmune disease is disclosed. Bacterial endotoxin/lipopolysaccaride (LPS) and unmethylated DNA (CpG DNA) of bacteria, the major pathogen-associated molecular patterns in sepsis and autoimmune disease, are specifically targeted, while the disclosed use directionally isolates lead compounds from traditional Chinese medicine. These measures can overcome the major defects of uncertainty of pharmacological material basis and drug targets of extracts and constituents of traditional Chinese medicine. The disclosed use can help in developing a safe, effective and quality controllable drug for prevention and treatment of sepsis and autoimmune disease so as to help solve the present lack of effective drugs in clinical treatment.