The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2018
Filed:
Aug. 31, 2016
Applicant:
Ludwig Institute for Cancer Research Ltd., New York, NY (US);
Inventors:
Vincenzo Cerundolo, Oxford, GB;
Simon Eastman, Delta, CA;
Assignee:
LUDWIG INSTITUTE FOR CANCER RESEARCH LTD., New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1272 (2013.01); A61K 9/1277 (2013.01); A61K 39/0011 (2013.01); A61K 45/06 (2013.01); A61K 2039/55555 (2013.01);
Abstract
The invention provides liposomes containing nonglycosidic ceramides within their bilayers, and compositions thereof. These liposomes activate murine iNKT cells and induce dendritic cell (DC) maturation, both in vitro and in vivo at an efficacy that is comparable to their corresponding soluble nonglycosidic ceramides. Also provided are methods for treating diseases using the liposomes and compositions of the invention.